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TUMOR NECROSIS FACTOR-ALPHA
Descriptors Found:
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DeCS
Descriptor
English
:
Tumor Necrosis Factor-alpha
Descriptor
Spanish
:
Factor de Necrosis Tumoral alfa
Descriptor
Portuguese
:
Fator de Necrose Tumoral alfa
Synonyms
English
:
Cachectin
TNF-alpha
Tumor Necrosis Factor Ligand Superfamily Member 2
Tree Number:
D12.644.276.374.500.800
D12.644.276.374.750.626
D12.776.124.900
D12.776.395.930
D12.776.467.374.500.800
D12.776.467.374.750.626
D23.529.374.500.800
D23.529.374.750.626
Definition
English
:
Serum glycoprotein produced by activated
MACROPHAGES
and other mammalian
MONONUCLEAR LEUKOCYTES
. It has necrotizing activity against tumor cell lines and increases ability to reject tumor
transplants
. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
History Note
English
:
2005(1988)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
29591
Unique Identifier:
D014409
Occurrence in VHL
:
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DeCS
CID-10
SciELO
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